Ormona® SI and Ormona® RC—New Nutraceuticals with Geranylgeraniol, Tocotrienols, Anthocyanins, and Isoflavones—Decrease High-Fat Diet-Induced Dyslipidemia in Wistar Rats

Dyslipidemia is a metabolic condition linked to increased morbidity. This study aimed evaluate the effect of two new nutraceuticals derived from annatto (Bixa orellana), açaí (Euterpe oleracea), and soybean germ or red clover isoflavones (Trifolium pratense) against high-fat-induced dyslipidemia in female Wistar rats. The formulations were assessed through GC-MS HPLC-UV/Vis. Next, rats received daily administrations coconut oil treated with Ormona® SI (OSI), RC (ORC), (SG), simvastatin (simv.), + (simv. OSI), only distilled water (control). Biochemical tests performed using animals’ blood, their arteries screened for atheroma formation. results show abnormal TC, TG, LDL, HDL levels caused by high-fat diet, glucose levels, hepatotoxicity, nephrotoxicity, atherogenesis. significantly ameliorated all conditions, that are similar group simvastatin. Notably, groups either had better liver protection than those SG simvastatin; additionally, could prevent atherogenesis, unlike SG. indicate high efficacy preventing its complications.